Title : Effects of Melatonin and Its Underlying Mechanism on Ethanol-Stimulated Senescence and Osteoclastic Differentiation in Human Periodontal Ligament Cells and Cementoblasts.

Pub. Date : 2018 Jun 12

PMID : 29895782






1 Functional Relationships(s)
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1 EtOH increased senescence activity, levels of reactive oxygen species (ROS) and the expression of cell cycle regulators (p53, p21 and p16) and senescence-associated secretory phenotype (SASP) genes (interleukin [IL]-1beta, IL-6, IL-8 and tumor necrosis factor-alpha) in HPDLCs and cementoblasts. Ethanol tumor protein p53 Homo sapiens