Pub. Date : 2018 Sep
PMID : 29890468
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-kappaB signal pathways in mice. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 4 | These results suggested that calycosin protects against AP by exerting anti-inflammatory and anti-oxidative stress effects via the p38 MAPK and NF-kappaB signal pathways. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |