Title : Javamide-II Found in Coffee Is Better than Caffeine at Suppressing TNF-α Production in PMA/PHA-Treated Lymphocytic Jurkat Cells.

Pub. Date : 2018 Jul 5

PMID : 29888601






3 Functional Relationships(s)
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1 Therefore, the inhibitory effect of javamide-II on TNF-alpha was investigated in PMA/PHA-treated lymphocytic Jurkat cells. javamide-ii tumor necrosis factor Homo sapiens
2 At 5 muM, javamide-II, not caffeine, inhibited TNF-alpha production in the cells (45 +- 4%, P < 0.001). javamide-ii tumor necrosis factor Homo sapiens
3 These data suggested that javamide-II may be a potent compound to suppress TNF-alpha production more efficiently than caffeine by inhibiting ERK phosphorylation in Jurkat cells. javamide-ii tumor necrosis factor Homo sapiens