Title : Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies.

Pub. Date : 2018 Jul 15

PMID : 29886321






1 Functional Relationships(s)
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1 Pleasingly, whereas compound 4 showed to be a highly potent inhibitor of AChE (IC50 = 6 nM) and binds to AChE-PAS to the same extent as donepezil, its prodrug 3 revealed to be inactive (IC50 > 10 muM). Aminosalicylic Acid acetylcholinesterase (Cartwright blood group) Homo sapiens