Title : Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression.

Pub. Date : 2018 Jun 4

PMID : 29867151






2 Functional Relationships(s)
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1 The proinflammatory mediator bradykinin stimulated cyclooxygenase-2 (COX-2) expression and subsequently prostaglandin E2 synthesis in dermal fibroblasts. Dinoprostone kininogen 1 Homo sapiens
2 Consequently, we concluded that bradykinin activates PKCepsilon via the PLD/PDK-1 pathway, which subsequently induces activation and translocation of ERK1 into the nucleus, and contributes to COX-2 expression for prostaglandin E2 synthesis in dermal fibroblasts. Dinoprostone kininogen 1 Homo sapiens