Title : miR-19 targeting of PTEN mediates butyl benzyl phthalate-induced proliferation in both ER(+) and ER(-) breast cancer cells.

Pub. Date : 2018 Oct 1

PMID : 29864457






2 Functional Relationships(s)
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1 In this study, we showed that BBP induced proliferation of both ER(+) MCF-7 and ER(-) MDA-MB-231 breast cancer cells, proved by increased cell viability, transition of cell cycle from G1 to S phase, upregulation of proliferating cell nuclear antigen (PCNA) and Cyclin D1, and downregulation of p21. butylbenzyl phthalate H3 histone pseudogene 16 Homo sapiens
2 Meanwhile, the expression of oncogenic miR-19a/b and PTEN/AKT/p21 axis was also modulated by BBP. butylbenzyl phthalate H3 histone pseudogene 16 Homo sapiens