Pub. Date : 2018
PMID : 29854846
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells. | Tretinoin | forkhead box P3 | Homo sapiens |
| 2 | All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells. | Tretinoin | forkhead box P3 | Homo sapiens |
| 3 | The addition of all-trans retinoic acid (ATRA) to human naive CD4+ cells could promote the maturation of Tregs and increase the stable expression of Foxp3. | Tretinoin | forkhead box P3 | Homo sapiens |
| 4 | The addition of all-trans retinoic acid (ATRA) to human naive CD4+ cells could promote the maturation of Tregs and increase the stable expression of Foxp3. | Tretinoin | forkhead box P3 | Homo sapiens |
| 5 | Results: The expression of Tregs and FOXP3 in CD4+ T cells from patients with SSc increased in response to ATRA. | Tretinoin | forkhead box P3 | Homo sapiens |
| 6 | Further studies revealed that stimulation with ATRA increased the expression of FOXP3 in SSc CD4+ T cells by downregulating FOXP3 promoter methylation levels. | Tretinoin | forkhead box P3 | Homo sapiens |
| 7 | Further studies revealed that stimulation with ATRA increased the expression of FOXP3 in SSc CD4+ T cells by downregulating FOXP3 promoter methylation levels. | Tretinoin | forkhead box P3 | Homo sapiens |
| 8 | Conclusions: ATRA acts as an inducer of Treg response in SSc CD4+ T cells via demethylation of the FOXP3 promoter and activation of FOXP3 expression. | Tretinoin | forkhead box P3 | Homo sapiens |
| 9 | Conclusions: ATRA acts as an inducer of Treg response in SSc CD4+ T cells via demethylation of the FOXP3 promoter and activation of FOXP3 expression. | Tretinoin | forkhead box P3 | Homo sapiens |