Title : Significance of calreticulin as a prognostic factor in endometrial cancer.

Pub. Date : 2018 Jun

PMID : 29844817






8 Functional Relationships(s)
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1 Low levels of CRT and an overexpression of Ki67 were significantly associated with the stage, histology, and differentiation of the primary surgery without doxorubicin (DOX) neoadjuvant chemotherapy (NAC) patient group and were significantly correlated with a short progression-free survival and the overall survival. Doxorubicin calreticulin Homo sapiens
2 Low levels of CRT and an overexpression of Ki67 were significantly associated with the stage, histology, and differentiation of the primary surgery without doxorubicin (DOX) neoadjuvant chemotherapy (NAC) patient group and were significantly correlated with a short progression-free survival and the overall survival. Doxorubicin calreticulin Homo sapiens
3 Low CRT expression and an overexpression of Ki67 were significantly associated with DOX-NAC and the histology (P<0.05) pre-NAC and post-NAC in the DOX-NAC patient group. Doxorubicin calreticulin Homo sapiens
4 Low CRT expression and an overexpression of Ki67 were significantly associated with DOX-NAC and the histology (P<0.05) pre-NAC and post-NAC in the DOX-NAC patient group. Doxorubicin calreticulin Homo sapiens
5 Upon treatment of DOX-NAC, CRT, PERK and p-eIF2alpha protein content were overexpressed in DOX-sensitive endometrial cancer (P<0.05), whereas there was no significant difference in the DOX-resistant group. Doxorubicin calreticulin Homo sapiens
6 Upon treatment of DOX-NAC, CRT, PERK and p-eIF2alpha protein content were overexpressed in DOX-sensitive endometrial cancer (P<0.05), whereas there was no significant difference in the DOX-resistant group. Doxorubicin calreticulin Homo sapiens
7 Upon treatment of DOX-NAC, CRT, PERK and p-eIF2alpha protein content were overexpressed in DOX-sensitive endometrial cancer (P<0.05), whereas there was no significant difference in the DOX-resistant group. Doxorubicin calreticulin Homo sapiens
8 CRT may therefore serve as a molecular marker for predicting the progression and prognosis in DOX-resistant endometrial cancer patients. Doxorubicin calreticulin Homo sapiens