Title : Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.

Pub. Date : 2018 May 29

PMID : 29843463






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ZMCs reactivate mutant p53 using a novel two-part mechanism that involves restoring the wild-type structure by reestablishing zinc binding and activating p53 through post-translational modifications induced by cellular reactive oxygen species (ROS). Reactive Oxygen Species tumor protein p53 Homo sapiens
2 ZMCs reactivate mutant p53 using a novel two-part mechanism that involves restoring the wild-type structure by reestablishing zinc binding and activating p53 through post-translational modifications induced by cellular reactive oxygen species (ROS). Reactive Oxygen Species tumor protein p53 Homo sapiens
3 ZMCs reactivate mutant p53 using a novel two-part mechanism that involves restoring the wild-type structure by reestablishing zinc binding and activating p53 through post-translational modifications induced by cellular reactive oxygen species (ROS). Reactive Oxygen Species tumor protein p53 Homo sapiens