Title : IL-3-producing basophils are required to exacerbate airway hyperresponsiveness in a murine inflammatory model.

Pub. Date : 2018 Dec

PMID : 29777594






3 Functional Relationships(s)
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1 RESULTS: We show that BMRB and basophils previously exposed to IL-3 differ in their ability to generate cytokines (IL-4, IL-6, IL-13, and GM-CSF) and histamine in response to FcepsilonRI crosslinking, reflecting two stages of maturation. Histamine interleukin 3 Mus musculus
2 Exposure to IL-3 initiated an autocrine loop of endogenous IL-3 production that enhanced histamine and cytokine production upon FcepsilonRI crosslinking. Histamine interleukin 3 Mus musculus
3 Exposure to IL-3 initiated an autocrine loop of endogenous IL-3 production that enhanced histamine and cytokine production upon FcepsilonRI crosslinking. Histamine interleukin 3 Mus musculus