Pub. Date : 2018 Aug
PMID : 29774469
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals. | Uric Acid | insulin | Homo sapiens |
| 2 | The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. | Uric Acid | insulin | Homo sapiens |
| 3 | The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. | Uric Acid | insulin | Homo sapiens |
| 4 | RESULTS: Subjects with higher levels of UA displayed an unfavorable metabolic phenotype with a worse lipid profile, increased levels of 2-h post-load glucose levels, fasting, and 2-h post-load insulin levels, hsCRP, liver IR index, and lower levels of eGFR and skeletal muscle insulin sensitivity, in comparison to individuals with lower UA levels. | Uric Acid | insulin | Homo sapiens |
| 5 | Moreover, subjects with higher UA concentrations exhibited decreased levels of insulin clearance even after adjustment for age, gender, BMI, eGFR, and skeletal muscle insulin sensitivity. | Uric Acid | insulin | Homo sapiens |
| 6 | In a multivariate regression analysis model including several confounding factors, UA concentration was an independent predictor of insulin clearance (beta = - 0.145; P = 0.03). | Uric Acid | insulin | Homo sapiens |
| 7 | However, when liver IR index was included in the model, the independent association between UA levels and insulin clearance was not retained. | Uric Acid | insulin | Homo sapiens |
| 8 | Accordingly, in a mediation analysis, liver IR index was a mediator of the negative effects of UA levels on insulin clearance (t = - 2.55, P = 0.01). | Uric Acid | insulin | Homo sapiens |
| 9 | CONCLUSIONS: Higher serum levels of UA may affect insulin clearance by impairing hepatic insulin sensitivity. | Uric Acid | insulin | Homo sapiens |