Pub. Date : 2018 Oct 15
PMID : 29769206
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | IDH2 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate; its mutated version leads to the accumulation of the oncometabolite (R)-2 hydroxyglutarate, which disrupts several cell processes and leads to a blockage in differentiation. | isocitric acid | isocitrate dehydrogenase (NADP(+)) 2 | Homo sapiens |