Title : Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.

Pub. Date : 2018 May 25

PMID : 29763808






1 Functional Relationships(s)
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1 In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Abeta-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2O2- and Abeta1-42-induced cytotoxicity. Metals acetylcholinesterase (Cartwright blood group) Homo sapiens