Pub. Date : 2018 Jul 15
PMID : 29763636
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Here, we investigated whether inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate (MSU) crystal-induced inflammation. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Virtual screening assay and in vitro enzyme inhibition assay showed that leonurine was a potential inhibitor of COX-2, mPGES-1 and 5-LOX. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Compared with COX-2 inhibitor celecoxib, leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the synovial fluid macrophages. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | Compared with COX-2 inhibitor celecoxib, leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the synovial fluid macrophages. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | In the in vitro cultured RAW264.7 and human monocyte-derived macrophages (MDMs), blockade of COX-2/mPGES-1 and 5-LOX by leonurine inhibited macrophage M1 polarization and NLRP3 inflammasome activation in response to MSU crystals, and thus down-regulated IL-1beta and TNF-alpha with STAT1 and NF-kappaB inactivation. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 7 | Furthermore, leonurine prevented a positive feedback loop between COX-2/mPGES-1/5-LOX and IL-1beta/TNF-alpha in MSU crystal-induced inflammation. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 8 | Together, simultaneous down-regulation of COX-2/mPGES-1 and 5-LOX by leonurine ameliorates MSU crystal-induced inflammation through decreasing IL-1beta and TNF-alpha production. | leonurine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |