Title : Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1.

Pub. Date : 2018 Jul 20

PMID : 29760016






2 Functional Relationships(s)
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1 When applied to cultured cardiomyocytes, insulin and metformin increased titin phosphorylation at S4010, S4099, and S11878 via enhanced ERK1/2 (extracellular signal regulated kinase 1/2) and PKCalpha (protein kinase Calpha) activity; NRG-1 application enhanced ERK1/2 activity but reduced PKCalpha activity. Metformin mitogen-activated protein kinase 3 Homo sapiens
2 When applied to cultured cardiomyocytes, insulin and metformin increased titin phosphorylation at S4010, S4099, and S11878 via enhanced ERK1/2 (extracellular signal regulated kinase 1/2) and PKCalpha (protein kinase Calpha) activity; NRG-1 application enhanced ERK1/2 activity but reduced PKCalpha activity. Metformin mitogen-activated protein kinase 3 Homo sapiens