Title : Wasabi 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human colorectal cancer cells through p53-independent mitochondrial dysfunction pathway.

Pub. Date : 2018 May 14

PMID : 29756671






4 Functional Relationships(s)
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1 Interestingly, 6-MSITC inhibited the cell proliferation in both types of cells with similar IC50 value although a light increase in the phosphorylation and accumulation of P53 protein was observed in HCT116 p53+/+ cells at 24 h after treatment. 6-(Methylsulfinyl)hexyl isothiocyanate tumor protein p53 Homo sapiens
2 Interestingly, 6-MSITC inhibited the cell proliferation in both types of cells with similar IC50 value although a light increase in the phosphorylation and accumulation of P53 protein was observed in HCT116 p53+/+ cells at 24 h after treatment. 6-(Methylsulfinyl)hexyl isothiocyanate tumor protein p53 Homo sapiens
3 In addition, 6-MSITC increased the ratio of proapoptotic cells in both types of cells with the same fashion in a p53-independent manner. 6-(Methylsulfinyl)hexyl isothiocyanate tumor protein p53 Homo sapiens
4 These findings suggest that 6-MSITC might be a potential agent for colon cancer chemoprevention although with p53 mutation. 6-(Methylsulfinyl)hexyl isothiocyanate tumor protein p53 Homo sapiens