Pub. Date : 2018 Sep
PMID : 29751037
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction of anti-cancer drug-cisplatin with major proteinase inhibitor-alpha-2-macroglobulin: Biophysical and thermodynamic analysis. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 2 | Alpha-2-macroglobulin is a multifunctional, highly abundant, plasma protein which reacts with a wide variety of molecules and drugs including cisplatin. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 3 | This study is designed to examine the interaction of cisplatin with human alpha-2-macroglobulin through various biophysical techniques and drug binding through molecular modeling. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 4 | Cisplatin alters the function of alpha-2-macroglobulin and the thiolesters are most likely the reactive sites for cisplatin. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 5 | Cisplatin alters the function of alpha-2-macroglobulin and the thiolesters are most likely the reactive sites for cisplatin. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 6 | Our result suggests that cisplatin decreases the antiproteolytic potential and causes structural and functional change in human alpha-2-macroglobulin as evident by absorption and fluorescence spectroscopy. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 7 | Thermodynamics parameters such as entropy (DeltaS), enthalpy (DeltaH) and Gibb"s free energy changes (DeltaG) along with number of binding sites (N) of alpha-2-macroglobulin-cisplatin binding in solutions were determined by isothermal titration calorimetry (ITC). | Cisplatin | alpha-2-macroglobulin | Homo sapiens |
| 8 | It was found that binding of cisplatin with alpha-2-macroglobulin was exothermic in nature. | Cisplatin | alpha-2-macroglobulin | Homo sapiens |