Title : Beta-elemene increases chemosensitivity to 5-fluorouracil through down-regulating microRNA-191 expression in colorectal carcinoma cells.

Pub. Date : 2018 Aug

PMID : 29737579






3 Functional Relationships(s)
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1 Increased apoptosis following beta-elemene exposure was due to enhanced sensitivity to 5-FU through down-regulating miR-191. beta-elemene microRNA 191 Homo sapiens
2 Expression of key kinases, including Wnt3a, and beta-catenin, were down-regulated by beta-elemene through a miR-191 mechanism. beta-elemene microRNA 191 Homo sapiens
3 Moreover, beta-elemene might improve resistance of colorectal carcinoma cells to 5-FU by down-regulating miR-191, thereby inhibiting the Wnt/beta-catenin pathway. beta-elemene microRNA 191 Homo sapiens