Title : Spiropyrrolidine/spiroindolizino[6,7-b]indole heterocyclic hybrids: Stereoselective synthesis, cholinesterase inhibitory activity and their molecular docking study.

Pub. Date : 2018 Sep

PMID : 29723743






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Most of the synthesized compounds showed good inhibitory activity, among them, compounds 4d and 4g displayed highest potency against AChE (IC50 1.88 and 1.98 muM), and BChE (IC50 18.32 and 10.21 muM) enzyme, respectively than the standard drug, galanthamine. Galantamine acetylcholinesterase (Cartwright blood group) Homo sapiens