Title : Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.

Pub. Date : 2018

PMID : 29715306






3 Functional Relationships(s)
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1 DEX inhibited IL-10 in newborn, and TNF, IL-1beta, IL-6 and interferon-alpha in newborn and adult blood. Dexamethasone interleukin 6 Homo sapiens
2 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Dexamethasone interleukin 6 Homo sapiens
3 (PTX+DEX) synergistically decreased LPS- and LPS/ATP-induced TNF, IL-1beta, and IL-6, and R848-induced IL-1beta and interferon-alpha, while (PTX+AZI) synergistically decreased induction of TNF, IL-1beta, and IL-6. Dexamethasone interleukin 6 Homo sapiens