Title : Effect of Tranexamic Acid on Blood Loss, D-Dimer, and Fibrinogen Kinetics in Adult Spinal Deformity Surgery.

Pub. Date : 2018 May 2

PMID : 29715224






4 Functional Relationships(s)
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1 The addition of tranexamic acid during a surgical procedure may mitigate the coagulopathy by impeding the derangement in D-dimer and fibrinogen kinetics. Tranexamic Acid fibrinogen beta chain Homo sapiens
2 The consumption of fibrinogen was 98.4 +- 42.6 mg/dL in the control cohort but was reduced in the tranexamic acid cohort to 60.6 +- 35.1 mg/dL (p = 0.004). Tranexamic Acid fibrinogen beta chain Homo sapiens
3 Monitoring of D-dimer and fibrinogen during spinal surgery suggests that tranexamic acid impedes the fibrinolytic pathway by decreasing consumption of fibrinogen and clot dissolution as evidenced by the reduced formation of D-dimer. Tranexamic Acid fibrinogen beta chain Homo sapiens
4 Monitoring of D-dimer and fibrinogen during spinal surgery suggests that tranexamic acid impedes the fibrinolytic pathway by decreasing consumption of fibrinogen and clot dissolution as evidenced by the reduced formation of D-dimer. Tranexamic Acid fibrinogen beta chain Homo sapiens