Title : NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review.

Pub. Date : 2018 Apr

PMID : 29702976






2 Functional Relationships(s)
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1 Here, we report a case of a Chinese patient with Sjogren syndrome (SS) with wild-type TPMT*3C who was diagnosed with AZA-induced severe toxicity due to NUDT15 mutation based on clinical and laboratory characteristics. Azathioprine thiopurine S-methyltransferase Homo sapiens
2 CONCLUSION: In this report, we first provide detailed clinical and laboratory characteristics of AZA-induced leukopenia in a patient with SS with a mutant NUDT15 R139C genotype (TT allele) and normal TPMT activity. Azathioprine thiopurine S-methyltransferase Homo sapiens