Pub. Date : 2018 Apr
PMID : 29702976
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review. | Azathioprine | nudix hydrolase 15 | Homo sapiens |
| 2 | Recent studies found that NUDT15 R139C polymorphism is strongly associated with AZA-induced leukopenia in Koreans. | Azathioprine | nudix hydrolase 15 | Homo sapiens |
| 3 | Here, we report a case of a Chinese patient with Sjogren syndrome (SS) with wild-type TPMT*3C who was diagnosed with AZA-induced severe toxicity due to NUDT15 mutation based on clinical and laboratory characteristics. | Azathioprine | nudix hydrolase 15 | Homo sapiens |
| 4 | CONCLUSION: In this report, we first provide detailed clinical and laboratory characteristics of AZA-induced leukopenia in a patient with SS with a mutant NUDT15 R139C genotype (TT allele) and normal TPMT activity. | Azathioprine | nudix hydrolase 15 | Homo sapiens |