Pub. Date : 2018
PMID : 29697034
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The chalcone class of compounds is well known to potently inhibit MAO-B, while nitrocatechol derivatives (e.g. tolcapone and entacapone) are clinically used COMT inhibitors. | Chalcone | monoamine oxidase B | Homo sapiens |
| 2 | CONCLUSION: This study shows that nitrocatechol derivatives of chalcone may act as COMT and MAO-B inhibitors, and proposes a general strategy for further enhancing MAO-B inhibition while retaining the potent COMT inhibition activity of this class. | Chalcone | monoamine oxidase B | Homo sapiens |
| 3 | CONCLUSION: This study shows that nitrocatechol derivatives of chalcone may act as COMT and MAO-B inhibitors, and proposes a general strategy for further enhancing MAO-B inhibition while retaining the potent COMT inhibition activity of this class. | Chalcone | monoamine oxidase B | Homo sapiens |