Title : Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters.

Pub. Date : 2018

PMID : 29689093






3 Functional Relationships(s)
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1 Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound. Sulfonamides latexin Homo sapiens
2 Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound. Sulfonamides latexin Homo sapiens
3 Both inhibitors were based on NS-1502 (IC50: 315 muM), but the deliberate placement of a sulfonamide group significantly improved the potency of JN-01 (IC50: 73.8 muM) and JN-02 (IC50: 112.8 muM) in comparison to the parent compound. Sulfonamides latexin Homo sapiens