Title : Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch.

Pub. Date : 2018 Aug

PMID : 29684582






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HUVEC transfection with a Let-7a anti-sense oligonucleotide reduced the ability of PMPs to inhibit THBS-1 release, and significantly decreased PMP induced in vitro angiogenesis. pmp thrombospondin 1 Homo sapiens
2 Antibody neutralisation of THBS-1 reversed the anti-angiogenic effect of let-7a inhibition in PMP treated HUVEC, highlighting Let-7a dependent translational repression of THBS-1 drives angiogenesis. pmp thrombospondin 1 Homo sapiens