Title : Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.

Pub. Date : 2018 Oct

PMID : 29671343






4 Functional Relationships(s)
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1 Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1. Pregnenolone sulfotransferase family 2A member 1 Homo sapiens
2 The cytosolic sulfotransferase (SULT) SULT2A1 is known to mediate the sulfation of DHEA as well as some other hydroxysteroids such as pregnenolone. Pregnenolone sulfotransferase family 2A member 1 Homo sapiens
3 The present study was designed to investigate how genetic polymorphisms of the human SULT2A1 gene may affect the sulfation of DHEA and pregnenolone. Pregnenolone sulfotransferase family 2A member 1 Homo sapiens
4 Enzymatic assays revealed that purified SULT2A1 allozymes displayed differential sulfating activity toward both DHEA and pregnenolone. Pregnenolone sulfotransferase family 2A member 1 Homo sapiens