Pub. Date : 2018
PMID : 29670920
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Methotrexate Combined with 4-Hydroperoxycyclophosphamide Downregulates Multidrug-Resistance P-Glycoprotein Expression Induced by Methotrexate in Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the JAK2/STAT3 Pathway. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined the signaling pathway involved. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | We investigated the effects of methotrexate (MTX) alone and combined with 4-hydroperoxycyclophosphamide (4-HC) on P-gp expression in fibroblast-like synoviocytes (FLSs) from patients with RA and examined the signaling pathway involved. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Results: MTX alone significantly induced P-gp expression and mRNA production in RA-FLSs. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | P-gp expression and mRNA levels were lower in the MTX + 4-HC group than in the MTX-alone group. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | P-gp expression and mRNA levels were lower in the MTX + 4-HC group than in the MTX-alone group. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 10 | Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 11 | Conclusions: The increased anti-P-gp effect of MTX + 4-HC versus MTX alone in RA-FLSs was mediated via inhibition of the JAK2/STAT3 pathway and may have helped reverse MDR in refractory RA patients with high-P-gp levels. | Methotrexate | ATP binding cassette subfamily B member 1 | Homo sapiens |