Pub. Date : 2018 Aug 1
PMID : 29668847
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Among the four down-stream soluble molecules of FXR, plasma adiponectin was most significantly increased by GW4064. | GW 4064 | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 2 | In cultured adipocytes, GW4064 increased mRNA levels and protein expression of adiponectin. | GW 4064 | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 3 | Conditioned medium of GW4064-treated adipocytes activated AMPK-PGC-1alpha signalling and reduced hypoxia-induced cardiomyocyte apoptosis, all of which were attenuated by an adiponectin neutralizing anti-body. | GW 4064 | adiponectin, C1Q and collagen domain containing | Mus musculus |
| 4 | More importantly, when knocking-out adiponectin in mice, the cardioprotective effects of GW4064 were attenuated. | GW 4064 | adiponectin, C1Q and collagen domain containing | Mus musculus |