Title : Multifunctional Hyaluronic Acid-Decorated Redox-Responsive Magnetic Complex Micelle for Targeted Drug Delivery with Enhanced Antitumor Efficiency and Anti-Cell-Migration Activity.

Pub. Date : 2018 Mar 1

PMID : 29663921






5 Functional Relationships(s)
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Protein Name
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1 A CSO-SS-Hex polymer micelle was used for PTX incorporation and GSH-triggered intracellular release. Paclitaxel hematopoietically expressed homeobox Homo sapiens
2 The HA/CSO-SS-Hex/Fe3O4/PTX micelle was stable under physiological conditions, while it was sensitive to release the loaded drug in the presence of 10 mM glutathione (GSH). Paclitaxel hematopoietically expressed homeobox Homo sapiens
3 Cell viability tests revealed that HA/CSO-SS-Hex/Fe3O4/PTX micelle displayed enhanced cytotoxicity against A549, B16F10 and HepG2 cell lines compared to non-targeted formulations of PTX. Paclitaxel hematopoietically expressed homeobox Homo sapiens
4 Cell viability tests revealed that HA/CSO-SS-Hex/Fe3O4/PTX micelle displayed enhanced cytotoxicity against A549, B16F10 and HepG2 cell lines compared to non-targeted formulations of PTX. Paclitaxel hematopoietically expressed homeobox Homo sapiens
5 Thus, the novel HA/CSO-SS-Hex/Fe3O4/PTX micelle is highly effective for targeted drug delivery and might have potential implications for the chemotherapy of primary tumors and their metastases. Paclitaxel hematopoietically expressed homeobox Homo sapiens