Pub. Date : 2018 Jul 18
PMID : 29652131
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thioflavin T Interaction with Acetylcholinesterase: New Evidence of 1:1 Binding Stoichiometry Obtained with Samples Prepared by Equilibrium Microdialysis. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | Despite the extended and active investigation of ThT-AChE binding, there is still no common view on the stoichiometry of this interaction. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | In particular, there is a hypothesis explaining the spectral properties of bound to AChE dye and high quantum yield of its fluorescence by formation of dimers or excimers of ThT. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 8 | In order to confirm or deny this hypothesis, we proposed a new experimental approach for examination of ThT-AChE interaction based on spectroscopic investigation of samples prepared by equilibrium microdialysis. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 9 | This approach allowed us to prove 1/1 ThT/AChE binding stoichiometry. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 10 | The increase of ThT fluorescence quantum yield and lifetime accompanying its binding to AChE can be explained by the molecular rotor nature of this dye. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 11 | Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 12 | Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 13 | Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 14 | The model of ThT localization in the active site of AChE was proposed by using molecular docking simulations. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 15 | These results also allowed us to suggest the key role of aromatic residues in ThT-AChE interaction, as observed for some amyloid fibrils. | thioflavin T | acetylcholinesterase (Cartwright blood group) | Homo sapiens |