Title : Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.

Pub. Date : 2018 May 10

PMID : 29649741






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both of them can be well docked into the acetyl-lysine (KAc) binding pocket of BRD4, forming key interactions including the critical hydrogen bonds with Asn140 directly and Tyr97 indirectly via a H2O molecule. Hydrogen bromodomain containing 4 Homo sapiens