Pub. Date : 2018 Jun 26
PMID : 29648801
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Proline biosynthesis and degradation involve the shared intermediate Delta1-pyrroline-5-carboxylate (P5C), which forms l-glutamate-gamma-semialdehyde (GSAL) in a reversible non-enzymatic reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 2 | Proline biosynthesis and degradation involve the shared intermediate Delta1-pyrroline-5-carboxylate (P5C), which forms l-glutamate-gamma-semialdehyde (GSAL) in a reversible non-enzymatic reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 3 | Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 4 | Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 5 | Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 6 | Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 7 | Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 8 | Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 9 | PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 10 | PRODH and PYCR form a metabolic relationship known as the proline-P5C cycle, a novel pathway that impacts cellular growth and death pathways. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 11 | The proline-P5C cycle has been implicated in supporting ATP production, protein and nucleotide synthesis, anaplerosis, and redox homeostasis in cancer cells. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 12 | This Perspective details the structures and reaction mechanisms of PRODH and PYCR and the role of the proline-P5C cycle in cancer metabolism. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 13 | A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 14 | A major challenge in the field is to discover inhibitors that specifically target PRODH and PYCR isoforms for use as tools for studying proline metabolism and the functions of the proline-P5C cycle in cancer. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 15 | These molecular probes could also serve as lead compounds in cancer drug discovery targeting the proline-P5C cycle. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |