Pub. Date : 2018 Apr 10
PMID : 29642616
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Scutellarin Mitigates Abeta-Induced Neurotoxicity and Improves Behavior Impairments in AD Mice. | scutellarin | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology. | scutellarin | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | After nine months of treatment in APP/PS1 double-transgenic mice, scutellarin significantly improves behavior, reduces soluble and insoluble Abeta levels in the brain and plasma, decreases Abeta plaque associated gliosis and levels of proinflammatory cytokines TNF-alpha and IL-6, attenuates neuroinflammation, displays anti-amyloidogenic effects, and highlights the beneficial effects of intervention on development or progression of AD-like neuropathology. | scutellarin | amyloid beta (A4) precursor protein | Mus musculus |