Pub. Date : 2018 Jul
PMID : 29635121
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | KEY FINDINGS: NAC at high concentrations normalized the peroxidase activity, H2O2, malondialdehyde (MDA), nitric oxide, glutathione (GSH), total antioxidant capacity (TAC), and interleukin 6 (IL-6) (overall change 34.32% +- 4.22%, P < 0.05 vs. LPS-treated). | Acetylcysteine | interleukin 6 | Homo sapiens |
| 2 | KEY FINDINGS: NAC at high concentrations normalized the peroxidase activity, H2O2, malondialdehyde (MDA), nitric oxide, glutathione (GSH), total antioxidant capacity (TAC), and interleukin 6 (IL-6) (overall change 34.32% +- 4.22%, P < 0.05 vs. LPS-treated). | Acetylcysteine | interleukin 6 | Homo sapiens |
| 3 | NAC at low concentrations modulated peroxidase activity, H2O2, MDA, GSH, TAC, and IL-6 (overall change 34.88% +- 7.39%, P < 0.05 vs. LPS-treated). | Acetylcysteine | interleukin 6 | Homo sapiens |
| 4 | NAC at very-low concentrations was effective on peroxidase activity, H2O2, GSH, and IL-6 (overall change 35.05 +- 7.71%, P < 0.05 vs. LPS-treated). | Acetylcysteine | interleukin 6 | Homo sapiens |
| 5 | Binary logistic regression analysis indicated that the modulatory effect of NAC on NKA levels was associated with a reduction of pro-oxidant factors and IL-6, and selectively blocking the NK2 receptor abolished such an association. | Acetylcysteine | interleukin 6 | Homo sapiens |
| 6 | SIGNIFICANCE: This study demonstrates that, along with its well-known antioxidant activity, the protective effect of NAC against the detrimental effect of LPS is due to the modulation of NKA and IL-6 levels. | Acetylcysteine | interleukin 6 | Homo sapiens |