Pub. Date : 2018 May 30
PMID : 29635055
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present work was to investigate the ability of nonionic surfactants to increase the oral absorption of the P-glycoprotein substrate etoposide in vitro and in vivo. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | In cell cultures, polysorbate 20 (PS20) decreased P-glycoprotein mediated efflux of etoposide. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | In conclusion, PS20 increases oral bioavailability of etoposide through inhibition of P-glycoprotein. | Etoposide | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |