Pub. Date : 2018 Jun
PMID : 29622583
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, in testing novel mutations with both prototypic endogenous (e.g., prostaglandin J2 [PGJ2]) and synthetic ligands (thiazolidinediones, tyrosine agonists), we observed that synthetic agonists selectively rescue function of some peroxisome proliferator-activated receptor-gamma (PPARgamma) mutants. | 9-deoxy-delta-9-prostaglandin D2 | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 2 | Furthermore, in testing novel mutations with both prototypic endogenous (e.g., prostaglandin J2 [PGJ2]) and synthetic ligands (thiazolidinediones, tyrosine agonists), we observed that synthetic agonists selectively rescue function of some peroxisome proliferator-activated receptor-gamma (PPARgamma) mutants. | 9-deoxy-delta-9-prostaglandin D2 | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 3 | Both PPARgamma mutants exhibit negligible constitutive or PGJ2-induced transcriptional activity but respond readily to synthetic agonists in vitro, with structural modeling providing a basis for such differential ligand-dependent responsiveness. | 9-deoxy-delta-9-prostaglandin D2 | peroxisome proliferator activated receptor gamma | Homo sapiens |