Title : O-Linked β-N-Acetylglucosamine Modification of A20 Enhances the Inhibition of NF-κB (Nuclear Factor-κB) Activation and Elicits Vascular Protection After Acute Endoluminal Arterial Injury.

Pub. Date : 2018 Jun

PMID : 29622561






3 Functional Relationships(s)
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1 Adenovirus-mediated A20 overexpression further enhanced the effects of thiamet G on prevention of TNF-alpha (tumor necrosis factor-alpha)-induced IkappaB (inhibitor of kappaB) degradation, p65 phosphorylation, and increases in DNA-binding activity. thiamet tumor necrosis factor Rattus norvegicus
2 Adenovirus-mediated A20 overexpression further enhanced the effects of thiamet G on prevention of TNF-alpha (tumor necrosis factor-alpha)-induced IkappaB (inhibitor of kappaB) degradation, p65 phosphorylation, and increases in DNA-binding activity. thiamet tumor necrosis factor Rattus norvegicus
3 A20 overexpression enhanced the inhibitory effects of thiamet G on TNF-alpha-induced proinflammatory cytokine expression and vascular smooth muscle cell migration and proliferation, whereas silencing endogenous A20 by transfection of specific A20 shRNA significantly attenuated these inhibitory effects. thiamet tumor necrosis factor Rattus norvegicus