Pub. Date : 2018 May
PMID : 29604489
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. | Simvastatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Accordingly, the TNF-induced elevation of neutrophil p50 activity was abolished by simvastatin. | Simvastatin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Simvastatin appears to inhibit neutrophil adhesion by interfering in TNF-induced cytoskeletal rearrangements, in association with the inhibition of Rho A activity, NFkappaB translocation and, consequently, beta2-integrin activity. | Simvastatin | nuclear factor kappa B subunit 1 | Homo sapiens |