Title : An experimental investigation of a novel iron chelating protoporphyrin IX prodrug for the enhancement of photodynamic therapy.

Pub. Date : 2018 Jul

PMID : 29603761






3 Functional Relationships(s)
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1 RESULTS: Generally, iron chelation achieved via CP94 or AP2-18 administration significantly increased PpIX fluorescence. protoporphyrin IX transcription factor AP-2 alpha Homo sapiens
2 AP2-18 was also at least as effective as CP94 + ALA/MAL co-administration throughout and significantly better than CP94 supplementation at increasing PpIX fluorescence in MRC5 cells as well as at lower doses where PpIX accumulation was observed to be more limited. protoporphyrin IX transcription factor AP-2 alpha Homo sapiens
3 AP2-18 was also at least as effective as CP94 + ALA/MAL co-administration throughout and significantly better than CP94 supplementation at increasing PpIX fluorescence in MRC5 cells as well as at lower doses where PpIX accumulation was observed to be more limited. protoporphyrin IX transcription factor AP-2 alpha Homo sapiens