Title : An experimental investigation of a novel iron chelating protoporphyrin IX prodrug for the enhancement of photodynamic therapy.

Pub. Date : 2018 Jul

PMID : 29603761






1 Functional Relationships(s)
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1 CONCLUSIONS: PpIX fluorescence levels, as well as PDT cell kill effects on irradiation can be significantly increased by pyridinone iron chelation, either via the addition of CP94 to the administration of a PpIX precursor or alternatively via the newly synthesized combined PpIX prodrug and siderophore, AP2-18. Pyridones transcription factor AP-2 alpha Homo sapiens