Title : NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis.

Pub. Date : 2018 Jul

PMID : 29602237






2 Functional Relationships(s)
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1 PGC-1alpha and Mfn-2 overexpression significantly decreased the NEFA-induced ROS production and TNF-alpha and IL-6 mRNA expressions, reversed the inhibitory effect of NEFAs on mitochondrial function and attenuated the overactivation of the ROS-JNK/p38MAPK pathway, alleviated insulin resistance induced by NEFAs in cow hepatocytes and HepG2 cells. Fatty Acids, Nonesterified insulin Bos taurus
2 PGC-1alpha and Mfn-2 overexpression significantly decreased the NEFA-induced ROS production and TNF-alpha and IL-6 mRNA expressions, reversed the inhibitory effect of NEFAs on mitochondrial function and attenuated the overactivation of the ROS-JNK/p38MAPK pathway, alleviated insulin resistance induced by NEFAs in cow hepatocytes and HepG2 cells. Fatty Acids, Nonesterified insulin Bos taurus