Title : Protective effects of kenpaullone on cardiomyocytes following H2O2-induced oxidative stress are attributed to inhibition of connexin 43 degradation by SGSM3.

Pub. Date : 2018 May 5

PMID : 29577900






4 Functional Relationships(s)
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1 Protective effects of kenpaullone on cardiomyocytes following H2O2-induced oxidative stress are attributed to inhibition of connexin 43 degradation by SGSM3. kenpaullone gap junction protein, alpha 1 Rattus norvegicus
2 Here, we investigated the protective effects of kenpaullone on cardiomyocytes following H2O2-induced oxidative stress mediated by the interaction of SGSM3 with Cx43. kenpaullone gap junction protein, alpha 1 Rattus norvegicus
3 Moreover, kenpaullone pretreatment significantly reduced ROS fluorescence intensity and significantly down-regulated the level of apoptosis-activating genes (cleaved caspase-3, cleaved caspase-9 and cytochrome C), autophagy markers (LC3A/B), and the Cx43-interacting partner SGSM3. kenpaullone gap junction protein, alpha 1 Rattus norvegicus
4 These results suggest that kenpaullone plays a role in protecting cardiomyocytes from oxidative stress and that the turnover of Cx43 through SGSM3-induced lysosomal degradation underlies the anti-apoptotic effect of kenpaullone. kenpaullone gap junction protein, alpha 1 Rattus norvegicus