Pub. Date : 2018
PMID : 29577851
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arachidonic acid is released by phospholipase A2 activity and clinical observations have shown a link between mutations in PLA2G6, the gene responsible for the production of phospholipase A2, and early-onset types of parkinsonism. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |
| 2 | Arachidonic acid is released by phospholipase A2 activity and clinical observations have shown a link between mutations in PLA2G6, the gene responsible for the production of phospholipase A2, and early-onset types of parkinsonism. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |
| 3 | It is unknown how phospholipase A2-driven release of arachidonic acid can affect the conformation of alphasynuclein. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |
| 4 | OBJECTIVE: The main objective of this study was to investigate if phospholipase A2-induced release of arachidonic acid can induce changes in conformation and aggregation state of alpha-synuclein. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |
| 5 | RESULTS: Phospholipase A2 is capable of releasing arachidonic acid from biomimetic phospholipid membranes. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |
| 6 | Exposure of alpha-synuclein to phospholipase A2-induced release of arachidonic acid from PC/PS liposomes induces a conformational transition of the protein and leads to partial resistance against proteolytic cleavage by V8 protease. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |
| 7 | Prolonged incubation of alpha-synuclein with arachidonic acid, derived from PC/PS liposomes by phospholipase A2 leads to aggregate formation. | Arachidonic Acid | phospholipase A2 group IB | Homo sapiens |