Pub. Date : 1987 Sep 1
PMID : 2957045
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Variation in the binding of 125I-labeled interferon-beta ser to cellular receptors during growth of human renal and bladder carcinoma cells in vitro. | Serine | interferon beta 1 | Homo sapiens |
| 2 | Studies of various established human bladder and renal carcinoma cell lines cultured in vitro demonstrated the presence of specific, saturable, high affinity binding sites for 125I-labeled human interferon Beta ser IFN-beta ser). | Serine | interferon beta 1 | Homo sapiens |
| 3 | Studies of various established human bladder and renal carcinoma cell lines cultured in vitro demonstrated the presence of specific, saturable, high affinity binding sites for 125I-labeled human interferon Beta ser IFN-beta ser). | Serine | interferon beta 1 | Homo sapiens |
| 4 | A single class of binding sites (1000-2000/cell) with an affinity constant of 10(10)-10(11) L/M was measured at 4 degrees C for cells exhibiting widely different sensitivity to the antiproliferative effect of IFN-beta ser. | Serine | interferon beta 1 | Homo sapiens |
| 5 | Major fluctuations in the binding of 125I-labeled IFN-beta ser to cellular receptors were observed during in vitro proliferation of four of five cell lines examined. | Serine | interferon beta 1 | Homo sapiens |
| 6 | Cell cycle analysis suggested that within the first 24 h and in the very late log and stationary phase of growth of ACHN (human renal carcinoma) cells, variations in the binding of 125I-labeled IFN-beta ser were partially attributable to binding fluctuations during the mitotic cycle. | Serine | interferon beta 1 | Homo sapiens |
| 7 | T24 (human transitional cell carcinoma) and ACHN cells, synchronized by serum starvation, demonstrated increased binding of 125I-labeled IFN-beta ser 4-16 h following serum replenishment. | Serine | interferon beta 1 | Homo sapiens |
| 8 | These changes in the biological activity of this interferon corresponded to growth related fluctuations in the IFN-beta ser binding. | Serine | interferon beta 1 | Homo sapiens |