Title : Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine.

Pub. Date : 2018 Dec

PMID : 29569712






1 Functional Relationships(s)
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1 The objective of this study was to determine if these relationships could be utilized to predict transporter induction by other CYP3A inducers (rifabutin and carbamazepine) and of another P-gp substrate, sofosbuvir. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens