Title : Leucine promotes differentiation of porcine myoblasts through the protein kinase B (Akt)/Forkhead box O1 signalling pathway.

Pub. Date : 2018 Apr

PMID : 29569540






5 Functional Relationships(s)
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1 Leucine promotes differentiation of porcine myoblasts through the protein kinase B (Akt)/Forkhead box O1 signalling pathway. Leucine thymoma viral proto-oncogene 1 Mus musculus
2 In addition, leucine increased the levels of phosphorylated Akt/Akt and phosphorylated Forkhead box O1 (P-FoxO1)/FoxO1, as well as decreased the protein level of FoxO1. Leucine thymoma viral proto-oncogene 1 Mus musculus
3 In addition, leucine increased the levels of phosphorylated Akt/Akt and phosphorylated Forkhead box O1 (P-FoxO1)/FoxO1, as well as decreased the protein level of FoxO1. Leucine thymoma viral proto-oncogene 1 Mus musculus
4 However, wortmannin, a specific repressor of PI3K/Akt signalling pathway, attenuated the positive role of leucine on porcine myoblast differentiation. Leucine thymoma viral proto-oncogene 1 Mus musculus
5 Our results suggest that leucine promotes porcine myoblast differentiation through the Akt/FoxO1 signalling pathway. Leucine thymoma viral proto-oncogene 1 Mus musculus