Title : Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells.

Pub. Date : 2018 Mar 2

PMID : 29568391






2 Functional Relationships(s)
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1 In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells. Proline peptidase D Homo sapiens
2 In these cells, glycyl-proline (GlyPro, substrate for prolidase) further inhibited DNA and collagen biosynthesis, maintained high prolidase activity, intracellular concentration of proline and up-regulated HIF-1alpha, AMPK, Atg7 and Beclin-1, compared to GlyPro-treated MCF-7 cells. Proline peptidase D Homo sapiens