Title : Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease.

Pub. Date : 2018 Mar 19

PMID : 29555950






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-beta (Abeta), and is enriched in senile plaques in brain of AD patients. Zinc amyloid beta precursor protein Homo sapiens
2 Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-beta (Abeta), and is enriched in senile plaques in brain of AD patients. Zinc amyloid beta precursor protein Homo sapiens
3 To understand Zn-chelated Abeta (ZnAbeta) species, here we systematically characterized ZnAbeta aggregates by incubating equimolar Abeta with Zn. Zinc amyloid beta precursor protein Homo sapiens