Pub. Date : 2018 Apr 15
PMID : 29551681
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interferon-gamma induces autophagy-associated apoptosis through induction of cPLA2-dependent mitochondrial ROS generation in colorectal cancer cells. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 2 | We observed that IFN-gamma induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 3 | We observed that IFN-gamma induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 4 | The IFN-gamma-induced mitochondrial ROS generation was dependent on the activation of cytosolic phospholipase A2 (cPLA2). | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 5 | In addition, a mitochondria-targeted antioxidant SS31 and/or cPLA2 inhibitor AACOCF3 abolished the IFN-gamma-induced ROS production and subsequent autophagy and apoptosis. | Reactive Oxygen Species | interferon gamma | Homo sapiens |
| 6 | Collectively, our results suggested that IFN-gamma induces autophagy-associated apoptosis in CRC cells via inducing cPLA2-dependent mitochondrial ROS production. | Reactive Oxygen Species | interferon gamma | Homo sapiens |